Table 3. Cox Regression Analysis for OS, LRFS, and DMFS.

OS: overall survival; LRFS: local recurrence-free survival; DMFS: distant metastasis-free survival; HR: hazard ratio

	OS				LRFS			DMFS
Covariates	Hazard  ratio	95% CI		P-value	HR	95% CI	P-value	HR	95% CI	P-value
TStage	1.41	1.04 - 1.91		0.027	1.154	0.86 - 1.54	0.327	1.808	1.43 - 2.29	< 0.001
N Stage	1.802		1.38 - 2.35	< 0.001	1.64	1.29 - 2.09	< 0.001	1.892	1.53 - 2.34	< 0.001
Grade	1.27		0.732 - 2.21	0.393	1.19	0.73 - 1.94	0.487	1.105	0.706 - 1.730	0.661
Molecular Type	1.737		1.39 - 2.17	< 0.001	1.66	1.36 - 2.02	< 0.001	1.644	1.371 - 1.973	< 0.001

Covariate	HR	95% CI	P value
Age (≤ 44 vs > 44)	0.809	0.44 - 1.49	0.498
Menopausal Status (pre vs post)	0.839	0.52 - 1.36	0.477
T-stage	1.94	1.53 - 2.46	< 0.001
N-stage	2.14	1.6 - 2.72	< 0.001
Tumor Grade	3.27	2.09 - 5.12	< 0.001
Histology	0.838	0.67 - 1.04	0.113
Chemotherapy	0.69	0.44 - 1.08	0.104
Boost	1.49	0.94 - 2.35	0.086
Molecular Subtypes	1.836	1.54 - 2.19	< 0.001