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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Mol Cancer Ther. 2016 Oct 28;16(1):35–44. doi: 10.1158/1535-7163.MCT-16-0186

Figure 5. Indocin enhances abiraterone treatment in vitro and in vivo.

Figure 5

A. CWR22Rv1cells were treated with 20 μM Indocin with or without 10 μM abiraterone for 2 days and total cell numbers were counted and cell survival rate was calculated. B. CWR22Rv1cells were treated with 20 μM Indocin with or without 10 μM abiraterone and clonogenic assays were performed; colonies were counted and results are presented as means ± SD of 2 experiments performed in duplicate, the representative pictures were taken under a microscope, C. Mice bearing CWR22Rv1 xenografts were treated with vehicle control, abiraterone acetate (200 mg/Kg p.o), Indocin (3mg/Kg i.p) or their combination for 3 weeks. Tumor volumes were measured twice weekly. D. Each group of tumors was weighed. E. IHC staining of Ki67 in each group was performed and quantified. *p<0.05. Abi: Abiraterone, Indocin: Indomethacin.