Table 2. Toxicity.

Patient number	Grade 1–2	Grade 3
1	Diarrhoea	–
2	Diarrhoea, anaemia, muscle pain, dyspnoea, cough, epistaxis, neuropathy, nausea/vomiting	Fatigue, thoracic pain due to constipation†.
3	Local superficial blood vessel reaction due to bortezomib	–
4	Loose stool, fatigue, skin rash, local soreness	Pneumonia‡
5	Nausea/vomiting, urinary coagels	–
6	Muscle cramps in lower extremities	Hypercalcemia
7	Neuropathy, blepharitis	–

^†, there was one instance of chest pain. The patient was immediately hospitalized and thoroughly examined. There was no evidence of a cardiovascular or pulmonary cause, and the reason was determined to be constipation. ^‡, there was one instance of grade 3 pneumonia. The patient was hospitalized for 3 days for intravenous penicillin. The patient continued the protocol after discharge and received the final vaccination. None of the patients experienced dose-limiting toxicities.