Figure 8.

Proposed Model

(A) 1: bpAPs activate dendritic VGCCs. 2: VGCC-mediated Ca²⁺ influx triggers Ca²⁺ release from the lysosome via an NAADP-sensitive channel. 3: lysosomal Ca²⁺ release triggers fusion of the lysosome with the plasma membrane, resulting in the release of Cathepsin B. 4: Cathepsin B cleaves TIMP-1, releasing MMP-9 from inhibition. 5: MMP-9 activity maintains the long-lasting structural plasticity of dendritic spines.

(B) Targets of pharmacological reagents used in this study.