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Concentration-response curves to (A,B) Ach and (C,D) 5-HT in aortic rings from ERα WT (A,C) and KO (B,D) mice receiving normal diet (SD), western diet (WD), or SD and WD containing polyphenols (SD + polyphenols and WD + polyphenols, respectively) during 12 weeks. The data are expressed as the mean ± SEM. Statistical analyses were performed by one-way ANOVA and Holm–Sidak’s post hoc test, ∗∗∗P < 0.001.
