TABLE 1.
Animal characteristics following 12 weeks of diets.
| WT |
KO |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| SD | SD + Polyphenols | WD | WD + Polyphenols | SD | SD+Polyphenols | WD | WD+Polyphenols | ||
| Initial body weight (bw, g) | 19:8 ± 0:4 | 19:5 ± 0:6 | 20:2 ± 0:6 | 19:3 ± 0:3 | 20:1 ± 1:1 | 19:6 ± 0:7 | 17:7 ± 1:1 | 20:3 ± 0:5 | |
| Final body weight (g) | 20:9 ± 0:6 | 20:1 ± 0:4 | 26 ± 0:5∗∗∗ | 23:5 ± 0:5§§ | 20:5 ± 0:9 | 19:6 ± 0:5. | 23:0 ± 1:6 | 27:6 ± 0:8¥¥¤¤¤¤ | |
| Liver weight (bw%) | 6:0 ± 0:3 | 5:4 ± 0:5 | 6:3 ± 0:3 | 6:0 ± 0:2 | 4:6 ± 0:2∗∗ | 4:8 ± 0:2 | 4:3 ± 0:2## | 4:5 ± 0:2 | |
| Heart (bw%) | 0:7 ± 0:03 | 0:7 ± 0:07 | 0:5 ± 0:03 | 0:6 ± 0:07 | 0:5 ± 0:05 | 0:5 ± 0:05 | 0:5 ± 0:03 | 0:4 ± 0:02 | |
| Visceral adipose tissue (bw%) | 3:6 ± 0:3 | 3:3 ± 0:5 | 8:5 ± 1:3∗∗∗ | 4:4 ± 0:5### | 2:8 ± 0:3 | 2:9 ± 0:3 | 5:6 ± 1:1 | 7:5 ± 0:9¥¤¤¤ | |
| Subcutaneous adipose tissue (bw%) | 1:7 ± 0:3 | 1:1 ± 0:2 | 3:9 ± 0:2∗∗ | 2:4 ± 0:4 | 1:9 ± 0:2 | 2:2 ± 0:2 | 5:0 ± 0:5†††† | 5:6 ± 0:7¤¤¤¤¥¥¥¥ | |
| Adiposity (bw%) | 5:3 ± 0:2 | 4:4 ± 0:5 | 12:4 ± 1:4∗∗∗∗ | 6:8 ± 0:7### | 4:7 ± 0:5 | 5:2 ± 0:5 | 10:6 ± 1:5†† | 13:1 ± 1:6¤¤¤¤¥¥¥ | |
The table shows the weight of mice, heart, visceral and subcutaneous adipose tissue and liver of ERα WT or KO mice fed with SD, WD, SD + Polyphenols or WD + Polyphenols for 12 weeks. The data are given as the mean ± SEM. Statistical analyses were performed by one-way ANOVA and Holm–Sidak’s post hoc test, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001, vs. WT SD group; §§P < 0.01 vs. WT SD + polyphenols group; ¥ < 0.05, ¥¥ < 0.0 vs. KO WD group; ¤¤¤P < 0.001, ¤¤¤¤P < 0.0001 vs. KO SD + polyphenols group; ##P < 0.01; ###P < 0.001 vs. WT WD group; ††P < 0.01, †††P < 0.0001 vs. KO SD group.