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. 2017 Jan 10;6:274. doi: 10.3389/fonc.2016.00274

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Copyright © 2017 Sundar, Bandla, Tan, Liao, Kumarakulasinghe, Jeyasekharan, Ow, Ho, Tan, Lim, Vijayan, Therimadasamy, Hairom, Ang, Ang, Thakor, Lee and Wilder-Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trend of skin temperature of the cooled (blue) vs. control (red) leg over the duration of limb hypothermia in breast cancer patients. Skin temperature was acquired continuously at various sensor locations: (A) below knee, (B) at the shin, (C) calf, (D) dorsum of the foot, (E) toe (hallux), (F) first metatarsal head, and (G) foot arch (foot plantar). Skin temperatures of the cooled leg showed significantly lower temperatures than the control leg at each time point (p < 0.05). Limb hypothermia was administered at a coolant temperature of 22°C throughout the duration of chemotherapy.