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. 2017 Jan 10;7:675. doi: 10.3389/fphys.2016.00675

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Copyright © 2017 Chacaroun, Borowik, Morrison, Baillieul, Flore, Doutreleau and Verges.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heart rate variability indices within the time domain [standard deviation of R–R interval (SDNN), (A,B); percentage of successive R–R that varied by 50 ms or more (PNN50), (C,D); root-mean-square difference of successive normal R–R intervals (RMSSD), (E,F)] during the first (S1) and the third (S3) sustained or intermittent hypoxia sessions. Data points are means ± SD. Gray areas indicate hypoxic phases. ^*Significantly different from normoxic baseline in both S1 and S3 (p < 0.05, two-way ANOVA main effect of time); ⁺Significantly different from normoxic baseline in S3 only (p < 0.05, two-way ANOVA session × time interaction); ^#Significantly different from normoxic baseline in S1 only (p < 0.05, two-way ANOVA session × time interaction); ^$Significant difference between S1 and S3 (p < 0.05, two-way ANOVA main effect of session or session × time interaction).