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. 2017 Jan 10;10:300. doi: 10.3389/fncel.2016.00300

Figure 5.

Figure 5

Blockage of HCN channels coupled to H2 receptors in the LVN attenuates spontaneous and the dimaprit-induced promotion on motor balance and coordination. (A,B) The endurance time on an accelerating rota-rod and the duration of passage through the balance beam of rats treated by bilateral microinjection of saline, 1 mM ZD7288, 3 mM ZD7288 or 10 mM ZD7288. (C,D) The decrement of motor performance in accelerating rota-rod and balance beam tests increased with the increase of the concentration of ZD7288. (E,F) The endurance time on an accelerating rota-rod and the duration of passage through the balance beam of rats treated by bilateral microinjection of dimaprit or dimaprit together with 3 mM ZD7288. Data shown are means ± SEM; *P < 0.05, **P < 0.01.