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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Oct 4;139(1):130–141.e11. doi: 10.1016/j.jaci.2016.07.020

Figure 4.

Figure 4

H,K-ATPase inhibitors decreased IL-13-induced eotaxin-3 protein secretion. A, BEAS-2Bs were pretreated for 2h with PPIs followed by IL-13 stimulation for 48h. Eotaxin-3 levels in supernatants were measured by using ELISA. B, Correlations between the measured IC50 of PPIs for IL-13-induced eotaxin-3 with published ED50 of PPIs for gastric pH42. C, SCH-28080 was used with the same protocol as A. Data represent means ± SEMs of three independent experiments. *P<.05, **P<.01, ***P<.001, ****P<.0001, compared with vehicle-treated/IL-13-stimulated cells (A and C).