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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Oct 4;139(1):130–141.e11. doi: 10.1016/j.jaci.2016.07.020

Figure 7.

Figure 7

Hypothetical model showing potential role of the ngH,K-ATPase in facilitating inhibitory effects of PPIs on IL-13-medicated eotaxin-3 expression. In addition to the canonical IL-13/STAT6 pathway, IL-13-mediated eotaxin-3 expression may be affected by the ngH,K-ATPase activity. The ngH,K-ATPase can be blocked by PPIs and other inhibitors including SCH-28080, ATP12A siRNA, and [K+]e-free solution, resulting in H+,K+-flux and pHi changes, which may affect expression of IL-13-mediated eotaxin-3.