Table 4.

Comparison of primary end point 3 and secondary endpoint: mean reduction in seven-point patient global impression of change (PGIC).

Studies	Number and percentage of patients who have improved (slightly, much and very much) at the end of the study		Number and percentage of participants who experienced any adverse events
	Treatment	Control	Treatment	Control
Backonja et al., 2008	114 (55%)	85 (43%),	203 (99%)	174 (88%)
Webster et al., 2010a	122 (55%)	32 (41%)	131 (59%)	43 (56%)
Webster et al., 2010b	41 (43%)	15 (30%)	76 (75%)	28 (53%)
Irving et al., 2011	123 (61%)	91 (47%)	208 (98%)	177 (87%)
Watson et al., 1993	91 (64%)	17 (25%)	45 (61%)	23 (33%)
Bernstein et al., 1989	4 (46%)	1 (6%)	NA	NA