Table 4.
In vitro antibiotic susceptibilities determined by macrodilution in TIGR4 and R6 strains of Streptococcus pneumoniae.
| Drug |
MIC μg/mL1 |
Fold change2 | |||
|---|---|---|---|---|---|
| TIGR4 | TIGR4ΔssrA | R6 | R6ΔssrA | ||
| Chloramphenicol | 1 | 0.5 | n.d. | n.d. | 2 ↓ |
| Tetracycline | 0.125 | 0.062 | n.d. | n.d. | 2 ↓ |
| Erythromycin | 0.03 | 0.0075 | n.d. | n.d. | 4 ↓ |
| Rifampicin | 0.06 | 0.03 | n.d. | n.d. | 2 ↓ |
| Penicillin | 0.016 | 0.016 | n.d. | n.d. | |
| Cefotaxime | 0.015 | 0.015 | n.d. | n.d. | |
| Moxifloxacin | 0.25 | 0.50 | 0.125 | 0.25 | 2 ↑ |
| Levofloxacin | 0.50 | 1 | 0.25 | 0.50 | 2 ↑ |
| Ciprofloxacin | n.d. | n.d. | 0.50 | 1 | 2 ↑ |
| Norfloxacin | n.d. | n.d. | 4 | 8 | 2 ↑ |
1Results are the average of at least three independent replicates. n.d., not determined. 2Fold change denotes the ration between the values for the wild type strains and their corresponding ΔssrA derivative.