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. 2016 Oct 31;161(1):63–72. doi: 10.1007/s10549-016-4033-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — CONSORT diagram. *Completed patients were those who stopped study treatment due to progressive disease