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. 2016 Dec 15;469(2):213–223. doi: 10.1007/s00424-016-1916-4

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — PIP₂ depletion prevents activation of whole-cell Kv7.4 currents by Gβγ. A Representative whole-cell currents evoked by depolarisation from −60 to +20 mV in Kv7.4 HEK293 cells under control conditions (a) and after incubation in wortmannin (20 μM, b). Right-hand panels show cells perfused internally with Gβγ. B Mean data for the effect of intracellular perfused active Gβγ on whole-cell currents recorded at +20 mV in the absence and presence of 20 μM wortmannin (n = 5)