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. 2016 Nov;186(11):2957–2969. doi: 10.1016/j.ajpath.2016.07.020

Figure 1.

Figure 1

Disease progression in PbN-infected mice treated with ET-1. A: Administration of exogenous ET-1 did not affect parasitemia in PbN-infected mice (nonsignificant difference for PbN versus PbN + ET-1; significant difference for PbA versus PbN and PbA versus PbN + ET-1). B: ET-1 treatment significantly accelerated mortality in PbN-infected mice [significant difference for the following comparisons: PbA versus PbN; PbA versus ET-1 and vehicle-treated uninfected mice (UN); PbN versus PbN + ET-1; PbN + ET-1 versus ET-1 and UN]. C: ET-1 treatment induced significant hypothermia (significant difference for the following comparisons: PbA versus PbN; PbA versus PbN + ET-1; PbA versus ET-1 and UN; PbN versus PbN + ET-1; PbN versus ET-1 and UN; PbN + ET-1 versus ET-1 and UN). D: ET-1 treatment also significantly worsened weight loss in PbN-infected mice at 7 days postinfection (significant difference for the following: PbA versus PbN + ET-1; PbA versus PbN; PbA versus ET-1 and UN; PbN versus PbN + ET-1; PbN versus ET-1 and UN; PbN + ET-1 versus ET-1 and UN). ∗P < 0.05.