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IL-6 induces matrix metallopeptidase (MMP)-13 expression upon SAHA treatment. Cultured chondrocytes were treated with 10 ng/mL IL-6 + 50 ng/mL sIL-6R for 12 hours and then supplemented with 1 μmol/L SAHA for an additional 12 hours. Chondrocytes were harvested and subsequently RNA and cDNA were prepared. MMP-13 expression was measured using TaqMan (Thermo Fisher/Life Technologies) real-time PCR assay. ∗∗P < 0.005. Con, control; sIL-6R, soluble IL-6 receptor.
