Figure 3.

Collagen (Col) 1 expression distinguishes between immune and matrix-oriented lung fibroblasts. Hung et al¹⁰ characterized the most enriched Kyoto Encyclopaedia of Genes and Genomes gene ontology pathways (www.genome.jp/kegg, last accessed June 2016) in the three FoxD1/Col1 fibroblast subsets in healthy lung. Immune and chemotaxis pathways are more enriched in FoxD1⁺/Col1⁻ cells, whereas matrix, adhesion, and developmental pathways are more strongly engaged in Col1⁺ cells. Top differentially expressed genes playing important roles in inflammation, tissue remodeling, and lung genesis, or degeneration were selected from the complete data set¹⁰ for discussion.