Table 2.
Phenotypes of Lineage-Traced Lung Pericytes, Resident Fibroblasts, and Precursors in Rodent Models
| Lineage | Locations |
Phenotypic markers |
Negative markers | References | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Perivascular | Interstitial | Subepithelial | PDGFR-β | PDGFR-α | NG2 | α-SMA | Col1 | |||
| Embryonic | ||||||||||
| Tbx4enh | + | + | − | + | − | CD31, cytokeratin | 8, 35 | |||
| − | − | + | − | CD31, cytokeratin | ||||||
| Healthy adult | ||||||||||
| Gli1 | + | − | + | + | + | − | − | CD31, CD45 | 20 | |
| Tbx4enh | + | − | + | ± | ± | CD31, T1α | 8 | |||
| PDGFR-α | + | − | + | + | + | − | ± | CD31 | 9 | |
| − | + | + | − | + | − | − | CD31 | |||
| FoxD1 (negative) | − | + | + | − | + | − | − | + | CD31, CD34, CD45, EpCAM, aquaporin V | |
| FoxD1 | + | − | − | + | + | + | − | + | CD31, CD34, CD45, EpCAM, aquaporin V | 10 |
| + | − | − | + | − | + | − | − | CD31, CD34, CD45, EpCAM, aquaporin V | ||
| FoxJ1 | + | − | − | + | − | 9 | ||||
| NG2 | + | − | − | + | + | − | CD31 | |||
| ABCG2 | + | − | + | + | − | − | − | CD31, CD45, CD133, CD144, CD146 | 17, 36 | |
| Bleomycin-injured adult | ||||||||||
| Gli1 | Fibrotic foci | + | + | − | + | CD31, CD45 | 20 | |||
| FoxD1+ | + | + | 10 | |||||||
| FoxJ1 | + | − | 9 | |||||||
| NG2 | + | + | − | CD31 | ||||||
| ABCG2 | + | − | − | + | CD31, CD45, CD133, CD144, CD146 | 17, 36 | ||||
Col, collagen; NG, neural/glial antigen; PDGFR, platelet-derived growth factor receptor; α-SMA, α-smooth muscle actin; +, present; –, absent.