Table 2. Percentage change of miRNAs expression in profiling phase.
| miRNA | Δ% |
95% CI |
RawP | P-FDR | |
|---|---|---|---|---|---|
| Lower | Upper | ||||
| miR-486-3p | −29.6% | −43.4% | −12.5% | 0.002 | 0.093 |
| miR-21 | −39.1% | −56.4% | −15% | 0.005 | 0.093 |
| miR-362-3p | −43.3% | −61.4% | −16.7% | 0.005 | 0.093 |
| miR-26a | −34.6% | −51.4% | −11.9% | 0.007 | 0.093 |
| miR-15b | −38.7% | −56.6% | −13.5% | 0.007 | 0.093 |
| miR-182 | −51.9% | −71.3% | −19.4% | 0.007 | 0.093 |
| miR-101 | −44.1% | −63% | −15.4% | 0.007 | 0.093 |
| miR-183 | −47.8% | −67.4% | −16.4% | 0.008 | 0.093 |
| miR-301a | −45.3% | −64.8% | −15% | 0.009 | 0.093 |
| miR-451 | −28.4% | −44.1% | −8.3% | 0.010 | 0.093 |
| miR-374a | −42% | −61.3% | −12.9% | 0.011 | 0.093 |
| miR-106b | −32.9% | −50.3% | −9.3% | 0.011 | 0.093 |
| miR-660 | −31.1% | −48.1% | −8.7% | 0.012 | 0.093 |
| miR-598 | −42.8% | −62.7% | −12.2% | 0.013 | 0.093 |
| miR-335 | −34.8% | −53.1% | −9.5% | 0.013 | 0.093 |
| miR-148b | −37.2% | −56% | −10.3% | 0.013 | 0.093 |
| miR-26b | −37.3% | −56.4% | −10% | 0.013 | 0.093 |
| let-7b | −27.9% | −44.2% | −6.8% | 0.015 | 0.093 |
| miR-18a | −38.6% | −58.1% | −9.8% | 0.015 | 0.093 |
| miR-126 | −43.9% | −64.7% | −11% | 0.016 | 0.093 |
| miR-192 | −25.7% | −41.3% | −5.8% | 0.017 | 0.093 |
| miR-22 | −29.1% | −46.3% | −6.4% | 0.018 | 0.093 |
| let-7 g | −35.6% | −54.9% | −8.1% | 0.018 | 0.093 |
| miR-19a | −27.8% | −44.5% | −6% | 0.018 | 0.093 |
| miR-103 | −31.4% | −49.7% | −6.5% | 0.020 | 0.096 |
| miR-142-5p | −32.7% | −51.6% | −6.4% | 0.021 | 0.099 |
| miR-374b | −33.6% | −53.2% | −5.8% | 0.024 | 0.099 |
| miR-106a | −32.1% | −51.4% | −5.3% | 0.025 | 0.099 |
| miR-132 | −29% | −47.1% | −4.6% | 0.026 | 0.099 |
| let-7e | −29.5% | −48% | −4.5% | 0.027 | 0.099 |
| miR-25 | −23.2% | −38.9% | −3.4% | 0.027 | 0.099 |
| miR-17 | −31.7% | −50.9% | −4.9% | 0.027 | 0.099 |
| miR-93 | −30.9% | −50.3% | −4% | 0.031 | 0.099 |
| miR-194 | −25.9% | −43.4% | −3.1% | 0.032 | 0.099 |
| miR-195 | −34.5% | −55.2% | −4.4% | 0.032 | 0.099 |
| miR-532-5p | −25.9% | −43.4% | −3% | 0.033 | 0.099 |
| miR-29c | −33.2% | −53.7% | −3.8% | 0.033 | 0.099 |
| miR-142-3p | −23.8% | −40.3% | −2.6% | 0.033 | 0.099 |
| miR-331-3p | −20.7% | −35.7% | −2.1% | 0.034 | 0.099 |
| miR-130b | −28.3% | −47% | −3% | 0.034 | 0.099 |
| let-7a | −30.5% | −50% | −3.3% | 0.034 | 0.099 |
| miR-340 | −32.9% | −53.3% | −3.6% | 0.034 | 0.099 |
| miR-24 | −23.4% | −39.9% | −2.3% | 0.035 | 0.099 |
Abbreviations: CI, confidence interval; Cr, chromium; FDR, false discovery rate; miRNA, microRNA.
The miRNA percentage change is expressed per 1% increment of Cr exposure. Models were adjusted for sex, age, BMI, granulocyte percentage and smoking habits. All miRNAs, P<0.10. The top 10 miRNAs (bold) were selected for validation.