Table 3. Percentage change of miRNA expression in validation phase.
| miRNA | Δ% | 95% CI | P-value | P-FDR | |
|---|---|---|---|---|---|
| Lower | Upper | ||||
| miR-451 | −73.2 | −85.1 | −51.6 | <0.001 | <0.001 |
| miR-301 | −95.3 | −98.9 | −78.8 | 0.000 | 0.001 |
| miR-15b | −83.5 | −94.0 | −54.5 | 0.001 | 0.003 |
| miR-21 | −80.3 | −92.5 | −48.6 | 0.001 | 0.004 |
| miR-26a | −75.7 | −89.7 | −42.6 | 0.002 | 0.004 |
| miR-362-3p | −88.7 | −97.1 | −56.7 | 0.002 | 0.004 |
| miR-182 | −74.0 | −89.5 | −35.5 | 0.005 | 0.007 |
| miR-183 | −77.8 | −94.9 | −4.0 | 0.048 | 0.060 |
| miR-486-3p | −74.8 | −94.1 | 6.8 | 0.065 | 0.072 |
| miR-101 | −30.5 | −69.3 | 57.5 | 0.387 | 0.387 |
Abbreviations: CI, confidence interval; Cr, chromium; FDR, false discovery rate; miRNA, microRNA.
The miRNA percentage change is expressed per 1% increment of Cr exposure in validation. Models were adjusted for sex, age, BMI, granulocyte percentage and smoking habits.