Table 2.

Negative regulators of TLR signaling involved in ubiquitination.

E3 ligase or adapter of E3 ligase complex	Target molecules	Ubiquitin-mediated modifications	Biological function
A20	RIP1, Ubc13	K48	Proteolytic degradation
Triad3A/RNF216	TLR3, TLR4, TLR5, TLR9, TIRAP, TRIP, RIP1	K48	Proteolytic degradation
SOCS1	TIRAP, IRAK, p65/RelA	K48	Proteolytic degradation
PDLIM2	P65/RelA	K48	Proteolytic degradation
COMMD1	P65/RelA	K48	Proteolytic degradation
TRIM27	IKKα, IKKβ	K48	Proteolytic degradation
TRIM38	TRAF6, TRIF, TAB2/3	K48	Proteolytic degradation