Table 1.
Independent Association Signals with Giant Cell Arteritis Susceptibility at the Genome-wide Level of Significance
| SNP | Location (GRCh37) | Locus | Change |
Meta-analysis |
Minor Allele Frequency (GCA/CTRL)a |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p Value | OR (CI 95%) | P(Q) | I2 | Spain | UK | Italy | North America | Germany | France | Norway | Netherlands | Switzerland | Ireland | ||||
| rs9268905 | 6:32432077 | HLA-DRA/HLA-DRB1 | C<G | 1.94 × 10−54 | 1.79 (1.67–1.93) | 0.75 | 0 | 0.46/0.32 | 0.52/0.37 | 0.33/0.23 | 0.48/0.32 | 0.39/0.28 | 0.48/0.29 | 0.47/0.33 | 0.37/0.28 | 0.42/0.34 | 0.45/0.34 |
| rs9275592 | 6:32680620 | HLA-DQA1/HLA-DQA2 | T<G | 1.14 × 10−40 | 2.08 (1.87–2.32) | 0.98 | 0 | 0.15/0.08 | 0.18/0.11 | 0.09/0.05 | 0.20/0.09 | 0.18/0.10 | 0.18/0.10 | 0.28/0.16 | 0.18/0.10 | 0.19/0.11 | 0.15/0.10 |
| rs4252134 | 6:161153527 | PLG | C<T | 1.23 × 10−10 | 1.28 (1.19–1.39) | 0.04 | 49 | 0.33/0.29 | 0.36/0.28 | 0.36/0.33 | 0.32/0.30 | 0.32/0.28 | 0.34/0.33 | 0.38/0.23 | 0.38/0.28 | 0.47/0.28 | 0.41/0.30 |
| rs128738 | 5:131540875 | P4HA2 | T<G | 4.60 × 10−9 | 1.32 (1.20–1.45) | 0.49 | 0 | 0.19/0.14 | 0.22/0.17 | 0.16/0.14 | 0.17/0.16 | 0.20/0.17 | 0.18/0.16 | 0.22/0.18 | 0.23/0.15 | 0.18/0.16 | 0.16/0.18 |
Abbreviations are as follows: GCA, giant cell arteritis; CTRL, controls; GRCh37, genome reference consortium human genome build 37; OR, per-allele odds ratio for the minor allele; CI, confidence interval; Q, Cochran’s Q test.
a
N (GCA/CTRL): Spain = 805/1,323, UK = 352/2,965, Italy = 271/960, North America = 176/1,181, Germany = 160/667, France = 114/488, Norway = 104/121, Netherlands = 69/638, Switzerland = 46/500, Ireland = 37/282, combined = 2,134/9,125.