Table 1.

All Loci Associated with the Concentration of at least One of the Studied Cytokines

Cytokine	Rs-id	Gene	Locus	Position	A1	A2	MAF	Info	Beta (SD)	SE (SD)	p Value	HetPVal
MCP1	rs12075	ACKR1	1q23.2	159175354	G	A	0.47	1.00	0.219	0.015	1.44 × 10−44	8.76 × 10−78
SCGFb	rs4656185	F5	1q24.2	169476326	G	A	0.29	1.00	0.205	0.026	1.16 × 10−15	7.37 × 10−6
IL-18	rs385076	NLRC4	2p22.3	32489851	T	C	0.34	0.97	0.243	0.025	1.66 × 10−22	0.07
PDGFbb	rs13412535	SERPINE2	2q36.1	224874874	G	A	0.19	0.87	0.335	0.021	2.46 × 10−55	1.86 × 10−10
Eotaxin	rs 2228467	ACKR2	3p22.1	42906116	T	C	0.07	1.00	0.416	0.029	2.27 × 10−46	0.02
MIP1b	rs113010081	CCRL2	3p21.31	46457412	T	C	0.13	0.89	0.595	0.024	3.85 × 10−140	0.33
IL-17	rs1530455	PDIA5	3q21.1	122854899	T	C	0.36	0.95	−0.108	0.017	4.71 × 10−10	0.81
TRAIL	esv2656942	TNFSF10	3q26.31	172274209	A	–	0.04	0.98	−0.431	0.041	1.74 × 10−25	0.74
HGF	rs3748034	HGFAC	4p16.3	3446091	G	T	0.12	0.97	0.150	0.023	1.79 × 10−10	0.50
GROa	rs508977	CXCL1	4q13.3	74762383	T	G	0.24	1.00	0.380	0.028	7.56 × 10−42	0.03
IP10	rs141053179	CXCL10	4q21.1	77589911	C	G	0.01	0.99	1.103	0.140	2.81 × 10−15	0.97
IL-18	rs17229943	OCLN	5q13.2	68682536	A	C	0.08	0.84	0.312	0.046	1.62 × 10−11	0.98
VEGF	rs6921438	VEGFA	6p21.1	43925607	G	A	0.47	0.98	−0.490	0.018	2.09 × 10−171	2.19 × 10−47
HGF	rs5745687	HGF	7q21.11	81359051	C	T	0.04	1.00	−0.307	0.041	2.71 × 10−14	0.29
VEGF	rs7030781	VLDLR	9p24.2	2686273	A	T	0.42	0.98	−0.137	0.017	2.57 × 10−15	0.01
CTACK	rs2070074	IL11RA	9p13.3	34649442	A	G	0.11	1.00	−0.447	0.037	1.79 × 10−32	5.55 × 10−5
IL-2ra	rs12722497	IL2RA	10p15.1	6095928	C	A	0.06	0.99	0.628	0.049	1.57 × 10−38	0.18
VEGF	rs10761731	JMJD1C	10q21.3	65027610	A	T	0.36	0.99	0.119	0.017	1.01 × 10−11	0.54
IL-18	rs71478720	IL18	11q23.1	112009605	C	T	0.24	0.99	−0.267	0.028	3.71 × 10−22	0.59
SCGFb	rs187503377	STAB2	12q23.3	104261835	C	T	0.02	0.93	0.965	0.097	1.34 × 10−23	0.07
IL-16	rs4778636	IL16	15q25.1	81591639	G	A	0.04	1.00	−0.727	0.063	1.11 × 10−30	0.22
PDGFbb	rs4965869	PCSK6	15q26.3	101990320	C	T	0.26	1.00	0.184	0.018	5.66 × 10−24	7.2 × 10−3
MIP1b	rs113877493	CCL4L1	17q12	34812273	C	T	0.17	0.92	−0.612	0.022	1.62 × 10−173	3.58 × 10−7
TRAIL	rs192989810	MEP1B	18q12.1	29783353	C	T	0.01	0.96	2.221	0.078	8.40 × 10−175	5.92 × 10−3
SCGFb	rs116924815	CLEC11A	19q13.33	51230733	C	T	0.03	0.97	0.608	0.074	1.74 × 10−16	0.03
MIF	rs2330634	MIF	22q11.23	24250795	C	G	0.37	0.99	−0.156	0.025	4.53 × 10−10	0.11
CTACK	rs201003839	PPARA	22q13.31	46534944	A	ACGGGC	0.27	0.99	0.190	0.027	2.42 × 10−12	1.36 × 10−3

The same locus is occasionally associated with more than one cytokine but only the strongest trait association is reported in the table. Allele 2 is the effect allele. Beta and SE are in SD units. All positions refer to human genome build 37. Info column reports the imputation quality metric calculated by the Impute2 software. HetPVal reports the effect size heterogeneity statistics between the cohorts.