Table 3.

Variants Previously Associated with Disease and Here Found to Be Associated with Cytokine Concentrations

Locus	Rs-id	Disease	Cytokine	Other Allele	Effect Allele/Disease Risk Increasing Allele	EAF	Beta (SD)	SE (SD)	p Value
3p21.31	rs7616215	Behcet disease	MIP1b	T	C	0.40	−0.142	0.016	4.8 × 10−19
3p21.31	rs13096142	celiac disease	MIP1b	C	T	0.29	−0.163	0.017	4.8 × 10−21
6p21.1	rs943072	ulcerative colitis	IL-12p70	T	G	0.11	0.155	0.025	3.3 × 10−10
6p21.1	rs943072	ulcerative colitis	VEGF	T	G	0.11	0.176	0.027	2.0 × 10−11
10p15.1	rs12722489	Crohn disease and multiple sclerosis	IL-2ra	T	C	0.87	0.325	0.034	4.1 × 10−21
10p15.1	rs12722515	inflammatory bowel disease	IL-2ra	A	C	0.87	0.328	0.034	1.6 × 10−21

Each variant reported in the table has been previously associated with corresponding disease or trait. p values denote the variant-cytokine association. Abbreviation: EAF, effect allele frequency.