Table 3.
Mouse QTL Validation of the Findings from MANTRA Trans-ethnic Analyses
| Trait | Chr | Gene |
Human (hg18/Build 36) |
Mouse (37 mm9) |
Significant and Suggestive Mouse QTLa |
LOD |
|---|---|---|---|---|---|---|
| (Chromosome:Position) | (Chromosome:Position) | Peak (95% CI) (Mb) | ||||
| Hct | 2 | TMEM163/ACMSD | chr2: 135,196,450–135,438,613 | chr1: 129,581,372–129,711,586b | 141.0 (54.8–158.9)∗ | 3.72∗ |
| Hct | 4 | SHROOM3 | chr4: 77,586,311–77,629,342 | chr5: 93,112,461–93,394,344 | 46.0 (19.6–106.5) | 2.34 |
| Hct | 7 | MET | chr7: 116,118,114–116,131,947 | chr6: 17,432,318–17,447,418b | 37.6 (6.6–127.9) | 2.75 |
| MCH | 8 | RBPMS | chr8: 30,400,375–30,400,375 | chr8: 34,893,115–35,040,335 | 78.9 (28.0–96.1)∗ | 3.98∗ |
| MCV | 3 | PLCL2 | chr3: 16,860,239–16,945,942 | chr17: 50,604,848–50,698,773b | 46.0 (28.6–55.3)∗ | 5.46∗ |
| MCV | 20 | FOXS1 | chr20: 29,684,484–29,897,013 | chr2: 152,576,419–152,758,874b | 170.1 (147.6–179.3)∗ | 4.69∗ |
a
Gene found in a significant (indicated with asterisk) or suggestive 95% CI mouse QTL, not corresponding to the human interval.
b
Within the corresponding human interval (±250 kb).