Table 2.
A summary of the C-type lectin receptors dealt with in this review
| Lectin | Expressed cell types | Ligands | Pathogens | Species |
||
|---|---|---|---|---|---|---|
| Human | Mouse | Plant | ||||
| MR | Møa, DCb subset, Lymphatic and hepatic endothelium | Mannose, Fucose, N-acetyl glucosamine, Sulphated sugar | Yeast, bacteria, HIVn, C. albicans, L. donovani, P. carinii, Klebsiella pneumonia, Trypanosoma cruzi, M. tuberculosis, capsular polysaccharides of S. pneumoniae | Ο | Ο | Ο |
| DC-SIGN | DC, dMøc, aMød | Mannose type CRD, Mannan, ManLam, ICAM-2, ICAM-3 | HIV, Mycobacterium tuberculosis, C. albicans, Leishmania mexicana, A. fumigatus, Helicobacter pylori, Schistosoma mansoni | Ο | Χ | Χ |
| SIGN-R1 | MZ Møe, pMøf | Mannose type CRD, Dextran, ICAM-3 | C. albicans, M. tuberculosis, S. pneumoniae, CPS, HIV, yeast-derived zymosan particles | Χ | Ο | Χ |
| Dectin-1 | DC, LCg, Mø, PMNh | β-glucan, T-cell ligand | C. albicans, Saccharomyces cerevisiae, Coccidioides posadasii, Pneumocystis carinii | Ο | Ο | Χ |
| Dectin-2 | H: Moi, Bj, Activated CD4+ Tk M: Mø, PMN, LC | Mannose type ligands, CD4/CD25+ T-cell ligand | C. Albicans | Ο | Ο | Χ |
| L-selectin | Leukocyte | s6SLex l | Arenavirus, Hantavirus, Coronavirus, Filovirus, Orthomyxovirus | Ο | Ο | Χ |
| P-selectin | Platelets, Endothelium | sLexm, s6SLex | HSVo, VZVp | Ο | Ο | Χ |
| E-selectin | Activated endothelium | sLex, s6SLex | Porphyromonas gingivalis | Ο | Ο | Χ |
aMø, alveolar macrophage; B, B cell; DCs, dendritic cells; dMø, decidual macrophage; HIV, Human immunodeficiency virus; HSV, Herpes simplex virus; LC, Langerhans cell; Mø, macrophage; Mo, monocyte; MZ Mø, marginal zone macrophage; pMø, peritoneal macrophage; PMN, polymorphonuclear cell; s6SLex, sialyl 6-sulpho Lewisx; sLex, sialyl Lewisx; T, T cell; VZV, Varicella zoster virus