Table 1. Patient characteristics.
| Parameter | Total no. (range/%) | pAML no. (range/%) | sAML no. (range/%) | P-value |
|---|---|---|---|---|
| Number of patients | 468 | 247 | 221 | |
| Median age, years | 64 (18–100) | 60 (18–93) | 68 (23–100) | <0.001 |
| Age>60 | 292 (62.4%) | 125 (50.6%) | 167 (75.6%) | <0.001 |
| Gender | ||||
| Male | 268 (57.3%) | 131 (53%) | 137 (62%) | 0.05 |
| Female | 200 (42.7%) | 116 (47%) | 84 (38%) | 0.05 |
| Clinical variables | ||||
| Median WBCx109/l | 7.3 (0.22–387) | 13 (0.5–298) | 3.85 (0.22–387) | <0.001 |
| WBC>15 000 | 171 (36%) | 121 (49%) | 50 (23%) | <0.001 |
| Median hemoglobin, g/dl | 9.1 (2.7–14) | 9 (4.6–14) | 9.3 (2.7–13.8) | 0.31 |
| Median plateletsx109/l | 52 (1–617) | 53 (6–351) | 50 (1–617) | 0.21 |
| Cytogenetic grouping | ||||
| Intermediate | 300 (64.1%) | 169 (68.4%) | 131 (59.3%) | 0.04 |
| Normal karyotype | 222 (47.4%) | 143 (57.9%) | 79 (35.7%) | |
| Unfavorable | 140 (29.2%) | 59 (23.9%) | 81 (36.7%) | 0.002 |
| Complex karyotype | 79 (16.9%) | 32 (13%) | 47 (21.3%) | |
| −5/del5q | 15 (3.2%) | 5 (2%) | 10 (4.5%) | |
| −7/del7q | 17 (3.6%) | 10 (4%) | 7 (3.2%) | |
| +8 | 29 (6.2%) | 12 (4.9%) | 17 (7.7%) | |
| Not available | 28 (6%) | 19 (7.7%) | 9 (4%) | |
Abbreviations: pAML, primary acute myeloid leukemia; sAML, secondary acute myeloid leukemia; WBC, white blood cell count.