Table 3. Multivariate Cox regression analysis comparing primary to secondary AML.

Parameter	Hazard ratio	95% Confidence interval	P-value
Diagnosis (primary vs secondary AML)	1.27	1.00–1.62	0.051
Age (⩽60 vs>60)	2.19	1.70–2.81	<0.001
Cytogenetic analysis (normal karyotype vs others)	1.00	0.74–1.35	0.992
Cytogenetic analysis (normal karyotype vs others)	2.35	1.71–3.24	<0.001
Cytogenetic analysis (normal karyotype vs others)	1.85	1.25–2.74	0.002
WBC (⩽15 000 vs >15 000)	1.44	1.12–1.84	0.004
DNMT3A	1.95	1.46–2.59	<0.001
ASXL1	1.72	1.19–2.48	0.004
EZH2	2.18	1.20–3.97	0.011
TP53	2.23	1.47–3.38	<0.001

Abbreviations: AML, acute myeloid leukemia; WBC, white blood cell count.