Table 3. Univariate and multivariate analysis for PFS and OS by Cox proportional hazards model.
| Variable |
Progression-free survival (PFS) |
Overall survival (OS) |
||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | P-value | Multivariate | P-value | Univariate | P-value | Multivariate | P-value | |
| Hazard ratio (95% CI) | Hazard ratio (95% CI) | Hazard ratio (95% CI) | Hazard ratio (95% CI) | |||||
| Age ⩾65 | 0.87 (0.72–1.05) | 0.144 | NA | NA | 1.09 (0.82–1.44) | 0.538 | NA | NA |
| HR FISH cytogenetics | 1.30 (1.05–1.60) | 0.015 | 1.20 (0.97–1.48) | 0.088 | 1.71 (1.24–2.32) | 0.001 | 1.26 (0.86–1.81) | 0.231 |
| CPCs present | 2.28 (1.87–2.76) | <0.0001 | 2.03 (1.64–2.50) | <0.001 | 2.97 (2.25–3.88) | <0.001 | 2.52 (1.78–3.55) | <0.001 |
| ⩾VGPR at transplant | 0.80 (0.67–0.95) | 0.012 | 1.15 (0.92–1.42) | 0.209 | 0.95 (0.72–1.24) | 0.727 | NA | NA |
| sCR post transplant | 0.45 (0.37–0.55) | <0.001 | 0.44 (0.34–0.55) | <0.001 | 0.42 (0.30–0.59) | <0.001 | 0.39 (0.25–0.61) | <0.001 |
| ISS stage 3 | 1.15 (0.94–1.41) | 0.168 | NA | NA | 1.48 (1.08–2.01) | 0.015 | 1.21 (0.86–1.70) | 0.270 |
| Reduced-dose melphalan | 1.03 (0.78–1.32) | 0.829 | NA | NA | 1.40 (0.96–1.99) | 0.076 | 1.27 (0.78–1.98) | 0.322 |
Abbreviations: CI, confidence interval; CPC, circulating plasma cells; FISH, fluorescence in situ hybridization; HR, high risk; ISS, International staging system; NA, not applicable; sCR, stringent complete response; VGPR, very good partial response. Bold values indicate statistically significance parameters.