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. 2017 Jan 10;7:40487. doi: 10.1038/srep40487

Figure 2. Elevated osteoclastic miR-214-3p level associates with increased bone resorption in bone specimens from BCX nude mice.

Figure 2

(a) The osteoclastic miR-214-3p levels (upper left), Oc.S/BS in proximal tibia (upper middle), serum CTX-I levels (upper right) and the representative images of TRAP staining in proximal tibia (bottom) were examined (n = 12 for each group). Scale bar: 100 μm. Arrow indicates TRAP-positive cells. The levels of miR-214-3p were normalized to the mean value of control group. (b) The correlation analysis between osteoclastic miR-214-3p level and Oc.S/BS and between osteoclastic miR-214-3p level and serum CTX-I levels was performed, respectively. Note: miR-214-3p levels were normalized to U6 and osteoclast marker genes mRNA levels were normalized to Gapdh. *P < 0.05 when compared to Week 1 in BCX mice.