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. 2017 Jan 10;7:40487. doi: 10.1038/srep40487

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Copyright © 2017, The Author(s)

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(a) A schematic diagram illustrating the experimental design. (b) ELISA analysis of serum CTX-1 level in mice from the indicated group after treatment. (c) The representative images for TRAP staining in the proximal tibiae bone sections from the indicated group after treatment. Arrow heads indicate osteoclasts. Scale bar: 50 μm. (d) The bone histomorphometric analysis for Oc.S/BS and N.Oc/B.Pm in the proximal tibiae bone sections from the indicated group after treatment. (e) The representative bioluminescence imaging showing the degree of metastasis in mice from the indicated group after treatment. (f) The bioluminescence signal intensity at the sites of bone metastasis (left) and non-bone metastasis (right) in the mice from the indicated group after treatment. (g) Representative micro-CT images showing the osteolytic bone lesion at proximal tibiae from the indicated group after treatment. Arrowheads indicate the osteolytic bone lesions. Scale bar = 1 mm. (h) The number of osteolytic lesion at proximal tibiae from the indicated group after treatment. Note: n = 12 for each group. The data were presented as the mean ± s.d., **P < 0.01. Control: nude mice without breast cancer xenografts, Model: breast cancer xenografted nude mice (BCX mice) administrated with PBS, Veh: BCX mice administrated with (D-Asp)₈-liposome, NC: BCX mice administrated with (D-Asp)₈-liposome-antagomir negative control, AMO: BCX mice administrated with (D-Asp₈)-liposome-antagomir-214-3p.