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. 2017 Jan 10;7:40285. doi: 10.1038/srep40285

Figure 1. Screen to determine the cardiac transdifferentiation-inducing effect of cardiac TF.

Figure 1

(A) HDF on day 0 prior to doxycycline addition. (B,C) Transduced HDF (M2rtTA and GFP) on day 1 or 14 post doxycycline addition. (D–P) HDF transduced with the various combinations of cardiac TF (according to table in panel Q). Expression of cardiac TFs was induced for 10 days. Immunofluorescence imaging for expression of ACTN2. White arrows indicate cells with significant ACTN2 expression in groups 2 and 7. (Q) Table detailing combinations of cardiac TFs being overexpressed in HDF.