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. 2017 Jan 10;7:40188. doi: 10.1038/srep40188

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Ribbon representation of the crystallographic structure of human GINS¹² (PDB ID: 2EHO) (b) Schematic diagram of the GINS subunits, highlighting the domain swap between the α-helical (A) and the β-rich (B) domains. (c) EM map of hGINS¹⁷ (EMD-1355) showing a C-shaped molecule. (d) To resolve the discrepancy between crystallographic and EM data a large rearrangement of the four GINS subunits has been proposed¹⁷.