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. 2017 Jan 10;7:40164. doi: 10.1038/srep40164

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Copyright © 2017, The Author(s)

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Nodes (green diamonds) represent the ICD disease chapters; they are shown with chapter number and short chapter name. Edges (blue lines) indicate potential correlations between diseases according to the transcriptional similarity of drugs. Node size indicates the sum of the edges of each node. Edge width indicates the number of drugs repositioned between two disease chapters. Chapter I: certain infectious and parasitic diseases (A00–B99); chapter II: neoplasms (C00–D48); chapter III: diseases of the blood, blood-forming organs, and certain disorders involving the immune mechanism (D50–D89); chapter IV: endocrine, nutritional, and metabolic diseases (E00–E90); chapter V: mental and behavioral disorders (F00–F99); chapter VI: diseases of the nervous system (G00–G99); chapter VII: diseases of the eye and adnexa (H00–H59); chapter VIII: diseases of the ear and mastoid process (H60–H95); chapter IX: diseases of the circulatory system (I00–I99); chapter X: diseases of the respiratory system (J00–J99); chapter XI: diseases of the digestive system (K00–K93); chapter XII: diseases of the skin and subcutaneous tissue (L00–L99); chapter XIII: diseases of the musculoskeletal system and connective tissue (M00–M99); chapter XIV: diseases of the genitourinary system (N00–N99); chapter XV: pregnancy, childbirth, and the puerperium (O00–O99); chapter XVI: certain conditions originating in the perinatal period (P00–P96); chapter XVII: congenital malformations, deformations; and chromosomal abnormalities (Q00–Q99); chapter XVIII: symptoms, signs, and abnormal clinical and laboratory findings not elsewhere classified (R00–R99); chapter XIX: injury, poisoning, and certain other consequences of external causes (S00–T98); chapter XX: external causes of morbidity and mortality (V01–Y98); chapter XXI: factors influencing health status and contact with health services (Z00–Z99); and chapter XXII: codes for special purposes (U00–U99).