Table 2. Identified differential amino acids in human plasma.
| Amino acids | Acute AD versus CHD | Chronic AD versus CHD | Acute AD versus Chronic AD | ||||||
|---|---|---|---|---|---|---|---|---|---|
| VIP | P | FC | VIP | P | FC | VIP | P | FC | |
| His | 1.30 | 0.022 | 0.82 | 1.13 | / | 0.90 | / | / | 0.91 |
| Gly | 1.31 | 0.033 | 0.77 | / | / | 0.94 | / | / | 0.82 |
| Ser | 1.15 | 0.053 | 0.79 | 1.11 | / | 0.87 | 1.00 | / | 0.91 |
| Cit | 1.85 | 0.001 | 0.57 | 1.81 | 0.005 | 0.74 | / | / | 0.77 |
| Orn | 1.30 | 0.020 | 0.69 | / | / | 0.88 | / | / | 0.78 |
| Hyp | 1.28 | 0.022 | 0.58 | 1.28 | / | 0.69 | / | / | 0.84 |
| Pro | 1.29 | 0.009 | 0.73 | / | / | 0.94 | 1.26 | / | 0.78 |
| Sar | 1.36 | 0.027 | 0.60 | 1.16 | / | 0.79 | / | / | 0.76 |
| GABA | 1.59 | / | 0.92 | 1.59 | 0.011 | 0.76 | / | / | 1.21 |
| Glu | 1.42 | / | 0.89 | 1.59 | 0.003 | 1.77 | 2.26 | 0.014 | 0.50 |
| Cys | / | / | 1.08 | 1.50 | 0.016 | 1.67 | / | / | 0.65 |
| Phe | / | / | 1.15 | / | / | 0.93 | 1.67 | 0.031 | 1.25 |
Variable important in projection (VIP) was obtained from PLS-DA with a threshold of 1.0; p-value was calculated from one way ANOVA; Fold change (FC) was calculated as the ratio of the mean amino acid levels between two groups.