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. 2017 Jan 10;18:12. doi: 10.1186/s12931-016-0496-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Ingenuity pathway analysis (IPA) of aberrant transcription in PSCC and ISCC. (i) The first heatmap column shows all IPA pathways that are significantly affected in ISCC (p-value < =0.05). The remaining 3 columns indicate the association of these IPA pathways with differentially expressed genes in all PSCC, high-grade PSCC or low-grade PSCC. (ii) This heatmap summarise the connection between IPA pathways significantly related to gene expression changes in ISCC (p-value < =0.05) and genes sorted by cluster analysis. Note that genes from cluster 8 were not linked to any IPA pathways associated with ISCC