Table 1.
Characteristics of NSCLC patients with brain metastasis
| Characteristics | Total (%) | RCT (%) | RT (%) | P |
|---|---|---|---|---|
| All patients | 238 (100) | 129 (100) | 109 (100) | |
| Gender | ||||
| Female | 102 (42.9) | 60 (46.5) | 42 (38.5) | 0.22 |
| Male | 136 (57.1) | 69 (53.5) | 67 (61.5) | |
| Smoking | ||||
| Never | 108 (45.4) | 63 (48.8) | 45 (41.3) | 0.24 |
| Current/former | 130 (54.6) | 66 (51.2) | 64 (58.7) | |
| Age | ||||
| ≤60 | 96 (40.3) | 58 (45.0) | 38 (35.9) | 0.11 |
| >60 | 142 (59.7) | 71 (55.0) | 71 (65.1) | |
| Histology | ||||
| Adenocarcinoma | 227 (95.4) | 123 (95.3) | 104 (95.4) | 0.98 |
| Non-adenocarcinoma | 11 (4.6) | 6 (4.7) | 5 (4.6) | |
| ECOG PS | ||||
| 0–1 | 188 (79.0) | 101 (78.3) | 87 (79.8) | 0.77 |
| 2–3 | 50 (21.0) | 28 (21.7) | 22 (20.2) | |
| Prior chemotherapy | ||||
| NO | 92 (38.7) | 51 (39.5) | 41 (37.6) | 0.76 |
| YES | 146 (61.3) | 78 (60.5) | 68 (62.4) | |
| Number of BM | ||||
| ≤3 | 65 (27.3%) | 33 (25.6%) | 32 (29.4%) | 0.52 |
| >3 | 173 (72.7%) | 96 (74.4%) | 77 (70.6%) | |
| Extracranial metastases | ||||
| NO | 93 (39.1%) | 48 (37.2%) | 45 (41.3%) | 0.52 |
| YES | 145 (60.9%) | 81 (62.8%) | 64 (58.7%) | |
| Primary disease control | ||||
| NO | 31 (13.0%) | 20 (15.5%) | 11 (10.1%) | 0.22 |
| YES | 207 (87.0%) | 109 (84.5%) | 98 (89.9%) | |
| RTOG RPA class | ||||
| ClassI | 50 (21.0%) | 31 (24.0%) | 19 (17.4%) | 0.21 |
| ClassII + III | 188 (79.0%) | 98 (76.0%) | 90 (82.6%) | |
| RTOG GPA grade | ||||
| 0–2 | 143 (60.1%) | 74 (57.4%) | 69 (63.3%) | 0.35 |
| 2.5–4 | 95 (39.9%) | 55 (42.6%) | 40 (36.7%) | |
Abbreviations: Eastern Cooperative Oncology Group performance status ECOG PS, Brain metastasis BM, the Radiation Therapy Oncology Group RTOG, recursive partitioning analysis RPA, graded prognostic assessment GPA