Table 5.
Toxicity profile for the NSCLC with brain metastasis patients treated by CRT and RT
| Side effects/N (%) | RCT arm (N = 129) | RT arm (N = 109) | P for all grades | P for grade III/IV | ||
|---|---|---|---|---|---|---|
| All grades | Grade III/IV | All grades | Grade III/IV | |||
| Fatigue | 81 (62.8) | 16 (12.4) | 68 (62.4) | 12 (11.0) | 0.95 | 0.74 |
| Anorexia | 64 (49.6) | 14 (10.9) | 47 (43.1) | 9 (8.3) | 0.29 | 0.50 |
| Diarrhea | 18 (13.9) | 0 (0%) | 12 (11.0) | 0 (0%) | 0.50 | NA |
| Nausea | 88 (68.2) | 29 (22.5) | 83 (76.1) | 20 (18.3) | 0.18 | 0.43 |
| Vomiting | 69 (53.5) | 14 (10.9) | 61 (56.0) | 13 (11.9) | 0.70 | 0.80 |
| Headache | 55 (42.6) | 13 (10.1) | 43 (39.4) | 11 (10.1) | 0.62 | 0.99 |
| Anemia | 72 (55.8) | 5 (3.9) | 61 (56.0) | 3 (2.8) | 0.98 | 0.91 |
| Neutropenia | 66 (51.2) | 13 (10.1) | 59 (54.1) | 10 (9.2) | 0.65 | 0.81 |
| Thrombocytopenia | 61 (47.3) | 4 (3.1) | 51 (46.8) | 2 (1.8) | 0.94 | 0.84 |