Table 4.
Effect of KA-induced excitotoxicity on TAS level in the cerebral cortex
| Subgroups | TAS (nanomoles/g wet tissue) Median (IqR) (n = 6) |
Kruskal-Wallis test (N = 30) | |||||
|---|---|---|---|---|---|---|---|
| CONTROL | KA | TH + KA | TPM + KA | ASP + KA | χ2 stat (df) | p value | |
| 2H | 789.62 (31.05) | 595.83 (45.37)a | 668.80 (17.05)a,b | 643.11 (21.43)a,b,c | 633.84 (27.71)a,b,c | 25.13 (4) | 0.0000 |
| 24H | 798.16 (17.27) | 533.40 (18.52)a | 631.66 (29.97)a,b | 643.32 (54.40)a,b | 601.23 (33.85)a,b,c | 23.69 (4) | 0.0001 |
| 48H | 797.59 (26.24) | 578.87 (8.92)a | 657.57 (34.49)a,b | 664.97 (41.12)a,b | 622.71 (20.48)a,b,c | 25.36 (4) | 0.0000 |
The results were expressed as the median (IqR). The significant difference was determined by non-parametric test, Kruskal-Wallis test followed by Mann-Whitney U post-hoc test with p < 0.05 indicates statistically significant difference. a p < 0.05 versus control group (MW); b p < 0.05 versus KA group (MW); c p < 0.05 versus KA + TH group (MW)