Table 2.
Univariate Cox proportional-hazard analysis of B-cell lymphoma prognostic gene signatures in GSE43664 and GSE39365 datasets
| Coef | Exp (coef) | SE (coef) | z score | P | |
|---|---|---|---|---|---|
| GSE43664 dataset | |||||
| Cfa.21188.1.S1_s_at: (CCND2) | -0.672 | 0.511 | 0.207 | -3.24 | 0.0012 |
| Cfa.19972.1.S1_at: (BCL2L14) | -3.44 | 0.0321 | 1.26 | -2.72 | 0.0065 |
| CfaAffx.18137.1.S1_at: (CR2) | -0.902 | 0.406 | 0.371 | -2.43 | 0.015 |
| CfaAffx.4397.1.S1_x_at: (PAX5) | -1.03 | 0.357 | 0.446 | -2.31 | 0.021 |
| Cfa.37.1.S1_at: (BIRC5) | -1.44 | 0.236 | 0.627 | -2.3 | 0.021 |
| Cfa.16248.1.S1_at: (CCND1) | -0.505 | 0.604 | 0.257 | -2.1 | 0.049 |
| Cfa.16217.1.S1_s_at: (CR2) | -0.527 | 0.59 | 0.272 | -1.94 | 0.052 |
| Cfa.182.1.S2_at: (HLA-DQA1) | -0.467 | 0.627 | 0.241 | -1.93 | 0.053 |
| Cfa.10937.1.S1_at: (LMO2) | -0.676 | 0.509 | 0.354 | -1.91 | 0.056 |
| CfaAffx.6511.1.S1_at: (MYCN) | -1.19 | 0.304 | 0.63 | -1.89 | 0.059 |
| Cfa.15639.1.A1_at: (TP53) | -0.373 | 0.688 | 0.202 | -1.85 | 0.064 |
| Cfa.5536.1.A1_at: (MYCN) | -0.781 | 0.458 | 0.443 | -1.76 | 0.078 |
| CfaAffx.18218.1.S1_at: (CR2) | -0.391 | 0.677 | 0.225 | -1.74 | 0.083 |
| CfaAffx.18149.1.S1_s_at: (CR2) | -0.429 | 0.651 | 0.248 | -1.73 | 0.083 |
| CfaAffx.18202.1.S1_s_at: (CR2) | -0.454 | 0.635 | 0.272 | -1.67 | 0.095 |
| Cfa.19191.1.S1_at: (PDE4B) | -0.857 | 0.425 | 0.518 | -1.65 | 0.098 |
| CfaAffx.4400.1.S1_at: (PAX5) | -1.65 | 0.192 | 1.05 | -1.58 | 0.11 |
| CfaAffx.11868.1.S1_at: (MYBL1) | -1.21 | 0.297 | 0.773 | -1.57 | 0.12 |
| Cfa.3707.1.A1_s_at: (FN1) | 0.622 | 1.86 | 0.415 | 1.5 | 0.13 |
| Cfa.3800.2.S1_at: (CD44) | 0.226 | 1.25 | 0.14 | 1.61 | 0.11 |
| CfaAffx.11235.1.S1_s_at: (CD44) | 0.259 | 1.3 | 0.142 | 1.82 | 0.068 |
| Cfa.127.1.S1_s_at: (PLAU) | 0.884 | 2.42 | 0.463 | 1.91 | 0.057 |
| Cfa.3707.2.S1_at: (FN1) | 0.277 | 1.32 | 0.129 | 2.15 | 0.031 |
| CfaAffx.22155.1.S1_s_at: (FN1) | 0.347 | 1.41 | 0.154 | 2.26 | 0.024 |
| Cfa.3707.3.S1_s_at: (FN1) | 0.827 | 2.29 | 0.336 | 2.46 | 0.014 |
| GSE39365 dataset | |||||
| Cfa.15826.1.S1_s_at: (BIRC5) | -0.832 | 0.435 | 0.477 | -1.74 | 0.081 |
| Cfa.16248.1.S1_at: (CCND1) | -0.923 | 0.397 | 0.54 | -1.71 | 0.088 |
| Cfa.5536.1.A1_at: (MYCN) | -2.44 | 0.0875 | 1.44 | -1.69 | 0.091 |
| Cfa.10937.1.S1_at: (LMO2) | -0.825 | 0.438 | 0.516 | -1.6 | 0.11 |
| Cfa.3619.1.S1_at: (CD38) | -0.804 | 0.448 | 0.512 | -1.57 | 0.12 |
| Cfa.3619.1.S1_s_at: (CD38) | -0.605 | 0.546 | 0.39 | -1.55 | 0.12 |
| CfaAffx.11868.1.S1_at: (MYBL1) | -1.76 | 0.171 | 1.16 | -1.52 | 0.12 |
| Clinical features (GSE39365 dataset) | |||||
| Age at diagnosis (years) | 0.0774 | 1.08 | 0.0893 | 0.866 | 0.39 |
| Sex | 0.165 | 1.18 | 0.576 | 0.287 | 0.77 |
| Grade | -1.04 | 0.354 | 0.68 | -1.53 | 0.13 |
Genes with z score higher than 1.5 or lower than -1.5 were listed. Exp (coef) indicates hazard ratio. Positive and negative z score denotes shorter and longer survival time respectively