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. 2017 Jan 2;216(1):231–246. doi: 10.1083/jcb.201601098

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© 2017 Bruckner et al.

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Figure 4. — Fife regulates synaptic probability of release. (A) In 0.2 mM Ca²⁺, Fife NMJs fail to respond to a presynaptic stimulus significantly more frequently than wild type (wild type: 1.8 ± 1.1%, n = 6 NMJs vs. Fife^ex^/^ex: 24.1 ± 6.6%, n = 11 NMJs; P = 0.007). (B) Representative traces of paired EJPs in wild type and Fife^AC/Df recorded in 0.6 mM Ca²⁺. (C and D) In 0.6 mM Ca²⁺, Fife NMJs facilitate significantly in response to paired pulses delivered at 20 Hz, as illustrated by representative traces scaled to the amplitude of the first wild-type pulse (C) and mean ratio of the amplitude of the first and second responses (D; wild type: 1.01 ± 0.04, n = 10 NMJs vs. Fife^AC/Df: 1.58 ± 0.16, n = 14 NMJs, P = 0.0004). The scale of EJPs in C is indicated by the black bar on the left for wild type and green bar on the right for Fife^AC/Df. **, P < 0.01; ***, P < 0.001; Mann–Whitney U test. Error bars represent SEM.