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Dots within the Manhattan plot display the identification of significant SNPs in the vicinity of CpG site leading to the meQTLs in the test model; the x-axis represents genomic position of SNPs, while the y-axis represents the −log P-value of the association between the SNPs and CpG sites. The red and blue lines indicate the threshold −log10(1 × 10−4) and −log10(0.05), respectively, for genome-wide statistical significance.
