Table 4.
Summary of univariate and multivariate analyses of SNP associations with overall risk based on the Cox PH model.
| SNP ID | CpG ID | GENE | LOCUS | UNIVARIATE HR 95% OF CI p | MULTIVARIATE HR 95% OF CI p |
|---|---|---|---|---|---|
| rs1862372 | cg09573435 | SEMA6A | 5q23.1 | 1.66 (0.66–4.15) 0.28 | 1.15 (0.2–6.3) 0.87 |
| rs2880556 | cg11929693 | LOC340073 | 5q31.3 | 2.23 (0.5–9.8) 0.29 | 59.7 (2.52–14.12) 0.011 |
| rs1548373 | cg03339247 | ZFHX3 | 16q22.3 | 2.35 (1.23–4.17) 0.0096 | 5.99 (1.84–19.49) 0.0029 |
| rs12591432 | cg15179472 | Intergenic | 15q23 | 1.32 (0.48–3.6) 0.59 | 4.50 (0.67–30.21) 0.12 |
| rs12653167 | cg04513214 | Intergenic | 5p15.1 | 2.96 (0.95–9.24) 0.062 | 4.85 (0.45–52.28) 0.19 |
| rs16943263 | cg14584565 | LOC283761 | 15q26.1 | 2.44 (0.68–8.6) 0.17 | 0.06 (0.0007–6.6) 0.25 |
| rs12085531 | cg01711124 | Intergenic | 1p36.12 | 0.52 (0.20–1.3) 0.17 | 1.4 (0.44–4.87) 0.53 |
| rs1538145 | cg15398976 | TRPC4 | 13q13.3 | 0.558 (0.29–1.07) 0.081 | 0.58 (0.21–1.54) 0.28 |
| rs41470747 | cg08980697 | RASGEF1B | 4q21.21 | 0.35 (0.13–0.94) 0.039 | 0.38 (0.047–3.07) 0.37 |
| rs140679 | cg04966682 | GABRG3 | 15q12 | 0.359 (0.15–0.82) 0.016 | 0.11 (0.018–0.7) 0.019 |
| rs17142291 | cg20214734 | ASB13 | 10p15.1 | 0.56 (0.15–2.0) 0.38 | 11.80 (0.47–291.84) 0.13 |
| rs11804125 | cg24310780 | LMX1A | 1q23.3 | 1.12 (0.56–2.2) 0.75 | 1.38 (0.34–5.47) 0.64 |
| rs7117026 | cg09939673 | DQ5982890 | 11p11.2 | 0.109 (0.03–0.3) 3.00 × 10−4 | 0.00198 (0.00003–0.12) 0.0034 |
| rs876701 | cg22675791 | DGKZ | 11p11.2 | 0.371 (0.14–0.94) 0.038 | 0.29 (0.07–1.27) 0.1 |
| rs574095 | cg24540569 | Intergenic | 1p31.3 | 0.445 (0.19–1.0) 0.058 | 0.25 (0.036–1.70) 0.16 |
| rs2286218 | cg20705812 | DLGAP2 | 8p23.3 | 2.76 (0.88–8.5) 0.08 | 0.97 (0.05–19.20) 0.99 |
Abbreviations: CI, confidence interval for the hazard ratio; HR, hazard ratio.