Fig. 4.

FGF14 knockdown changes intrinsic membrane properties and action potential generation. (A) The input resistance of 14KD neurons is higher than for Scr neurons. (B) Examples of action potential trains generated from 100-pA injections into both Scr and 14KD neurons. In 14KD neurons, the rise in interspike voltage during the current injection step is higher. Quantification is shown in C. (D) The threshold for action potentials subsequent to the first action potential of a train is higher in 14KD neurons than it is in Scr control neurons. (E) Increasing current injections lead to decreased numbers of action potentials generated from 14KD neurons compared with Scr neurons. (*P < 0.05, Student’s t test; n = 11–15 cells each).