Table S2.
Significantly (more than twofold) elevated mRNA and brief description of function
| mRNA | Description |
| Adm | Encodes for Adrenomedullin with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity |
| Agt | Encodes for angiotensinogen precursor; plays a role in regulation of blood pressure |
| Bcl2a1 | Encodes for BCL-2 protein; direct transcription target of NF-kappa B in response to inflammatory mediators; up-regulated by GM-CSF, CD40, TNF, and IL-1; anti-apoptotic and cell survival |
| Birc3 | Encodes for inhibition of apoptosis |
| C3 | Encodes for complement component C3; likely involved in innate immune response |
| Ccl11 | Encodes protein that has chemotactic activity for eosinophils, Eotaxin |
| Ccl12 | Encodes for monocyte chemoattractant protein-5 |
| Ccl22 | Encodes for chemoattractant for dendritic cells, NK cells, and the Th2 T cell |
| Ccl5 | Encodes for RANTES |
| Cd40 | Encodes for the TNF-receptor superfamily mediating a broad variety of immune and inflammatory responses |
| Cd83 | Encodes for the Ig superfamily of receptors |
| Csf2rb | Encodes for the high-affinity receptor for IL-3, IL-5, and CSF |
| Csf3 | Encodes for a cytokine that controls the production, differentiation, and function of granulocytes G-CSF |
| Cxcl1 | Encodes for growth-related protein 1 (Gro1); acts as a neutrophil chemoattractant; may play a role in acute-phase inflammatory response |
| Cxcl10 | Encodes for a chemokine for the receptor CXCR3 IFNγ-induced protein 10 (IP10) |
| Cxcl3 | Encodes for protein; plays a role in inflammation and as a chemoattractant for neutrophils, growth-related protein 3 (GRO3), and macrophage inflammatory protein (MIP2β) |
| Cxcl9 | Encodes for a protein thought to be involved in T-cell trafficking; monokine induced by IFNγ (MIG) |
| Egr2 | Encodes early growth response 2 protein |
| Icam1 | Encodes ICAM1 protein |
| Il1a | Encodes IL1α protein |
| Il1b | Encodes IL1β protein |
| Il1r2 | Encodes IL1R2 protein |
| Il1rn | Encodes IL1R antagonist protein |
| IL4 | Encodes IL4 protein |
| Il6 | Encodes IL6 protein |
| Ins2 | Encodes for insulin |
| Irf1 | Encodes for IFN regulatory factor 1 |
| Mmp9 | Encodes for MMP9 |
| Myc | Encodes a multifunction protein that plays a role in cell-cycle progression, apoptosis, and cellular transformation |
| Nfkb2 | Encodes for NFκb2 |
| Nfkbia | Encodes for for NFκb inhibitor α |
| Nr4a2 | Encodes for protein steroid-thyroid hormone-retinoid receptor superfamily and may act as a transcription factor |
| Plau | Encodes for serine protease involved in degradation of the extracellular matrix |
| Ptgs2 | Encodes for prostaglandin G/H synthase and cyclooxygenase |
| Sele | Encodes for E-Selectin |
| Selp | Encodes for P-Selectin |
| Stat3 | Encode for the STAT 3 protein family that is activated through phosphorylation in response to various cytokines and growth factors |
| Tnf | Encodes for TNF |
| Tnfrsf1b | Encodes for TNFR superfamily1 b |
The descriptions of function were abstracted from https://www.ncbi.nlm.nih.gov/gene.