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. 2016 Dec 16;114(1):E85–E94. doi: 10.1073/pnas.1606909114

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Fig. S4. — Histology of p48-Cre;Kras^G12D;CXCL12^lox/+ and p48-Cre;CXCL12^lox/+ mice. (A) Because of the distorted appearance of the lymph nodes in the p48-Cre;Kras^G12D;CXCL12^lox/+ mice, we performed immunolabeling against the exocrine cell marker pan-cytokeratin to detect metastatic cells. There were no exocrine cells in these distorted lymph nodes, thus excluding metastasis-induced damage to the lymph node structure as a cause of distortion. (B) p48-Cre;CXCL12^lox/+ mice were used as control animals to study the effects of heterozygous Cxcl12 ablation on the pancreatic morphology. There were no obvious differences in pancreatic morphology from normal wild-type pancreas.