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Schematic summary of prior findings. Kmt2d+/βGeo mice on a mixed C57BL/6J and 129SvEv background demonstrated a global deficiency of the open chromatin mark H3K4me3 in association with decreased neurogenesis in the GCL of the DG (Middle) compared with littermate Kmt2d+/+ mice (Left). These defects were rescued with AR-42 (Right) (6), a class 1 and 2 histone deacetylase inhibitor (24), which has recently been shown to inhibit HDAC5 in liver cells (49).
