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. 2016 Oct 3;45(1):231–243. doi: 10.1093/nar/gkw887

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — DSB-induced gene conversion. (A) An overview of the DSB-induced DNA sequence changes responsible for Ig reversion. Ig light chain V gene diversity was analyzed in sorted GFP (+) AID^−/− IgL^{Sce GFP} Tet-On^I-SceI DT40 cells recovered after dox treatment. Sequence changes, classified into gene conversion, NHEJ, alternative NHEJ (A-NHEJ), and non-templated insertion, are summarized on the map. (B) Sequences around the I-SceI site with detailed gene conversion analysis. (C) ψV usage and gene conversion tract length observed in DSB-induced gene conversion. (D) Sequence changes for successive gene conversion events. Gene conversion tracts are underlined and annotated with the name of the likely ψV donors.