Table 1.

Study Odds Ratios by treatment group in entire cohort.

	Mortality
Study	Reported 28-day outcomes	7-day outcomes (Youden’s index)
ARMA (high versus low tidal volume ventilation)	1.65 (1.24–2.21)	1.83 (1.36, 2.47)
ALVEOLI (high PEEP vs. low PEEP)	0.97 (0.64–1.47)	0.84 (0.53, 1.33)
FACTT (liberal vs. conservative fluid strategy)	1.20 (0.89–1.63)	1.55 (1.13, 2.12)
ACURASYS (Cisatracurium v. Placebo)	0.62 (0.39–1.00)	0.75 (0.45, 1.23)
	Prolonged ventilation
ARMA	1.39 (1.07, 1.81)	1.32 (1.01, 1.73)
ALVEOLI	1.05 (0.74, 1.49)	0.98 (0.67, 1.42)
FACTT	1.57 (1.19, 2.08)	1.65 (1.26, 2.16)
ACURASYS	0.65 (0.37, 1.15)	0.83 (0.50, 1.39)

Definitions of abbreviations: ACURASYS= ARDS et Curarisation Systematique, ALVEOLI= Assessment of Low Tidal Volume and elevated End-expiratory volume to Obviate Lung Injury, ARMA= Lower versus Traditional Tidal Volumes for ARDS, FACTT= Fluid and Catheter Treatment Trial, OI= Oxygenation Index

Youden’s Index= The index is defined for all points of an ROC curve (supplementary figure 2), and the maximum value of the index was used as a criterion for selecting the optimum cut-off point.

Data are relative risk ratios and 95% CI